[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers

J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Supersaturation and phase behavior during dissolution of amorphous solid dispersions

Y Kong, W Wang, C Wang, L Li, D Peng… - International Journal of …, 2023 - Elsevier
Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

Nanofluids: Critical issues, economics and sustainability perspectives

S Mukherjee, S Wciślik, PC Mishra, P Chaudhuri - Particuology, 2023 - Elsevier
According to the Scopus database, every year several hundreds of new research papers are
published in the field of nanofluids. This area is attracting growing attention because of the …

Stabilizing mechanisms of β-lactoglobulin in amorphous solid dispersions of indomethacin

A Kabedev, X Zhuo, D Leng, V Foderà… - Molecular …, 2022 - ACS Publications
Proteins, and in particular whey proteins, have recently been introduced as a promising
excipient class for stabilizing amorphous solid dispersions. However, despite the efficacy of …

Thermodynamic modeling of the amorphous solid dispersion-water interfacial layer and its impact on the release mechanism

S Dohrn, SO Kyeremateng, E Bochmann, E Sobich… - Pharmaceutics, 2023 - mdpi.com
During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …

Pharmaceutical profiling and molecular dynamics simulations reveal crystallization effects in amorphous formulations

K Edueng, A Kabedev, A Ekdahl, D Mahlin… - International Journal of …, 2022 - Elsevier
Robust and reliable in vivo performance of medicines based on amorphous solid
dispersions (ASDs) depend on maintenance of physical stability and efficient …

Predicting Surface pH in Unbuffered Conditions for Acids, Bases, and Their Salts–A Review of Modeling Approaches and Their Performance

T Casalini, J Mann, X Pepin - Molecular Pharmaceutics, 2023 - ACS Publications
Dissolution of ionizable drugs and their salts is a function of drug surface solubility driven by
the surface pH, ie, the microenvironmental pH at the solid/liquid interface, which will deviate …

Benchmarking the Solubility Enhancement and Storage Stability of Amorphous Drug–Polyelectrolyte Nanoplex against Co-Amorphous Formulation of the Same Drug

LM Lim, JW Park, K Hadinoto - Pharmaceutics, 2022 - mdpi.com
Amorphization, typically in the form of amorphous solid dispersion (ASD), represents a well-
established solubility enhancement strategy for poorly soluble drugs. Recently, two …

Performance Optimization Model of Molecular Dynamics Simulation Based on Machine Learning and Data Mining Algorithm

K Chen, K Zeng - Mobile Information Systems, 2022 - Wiley Online Library
Molecular dynamics simulation is an effective method for related research in the microscopic
world, mainly related to molecular atomic research, and it has a wide range of applications …

[PDF][PDF] Correlating rheological behavior with molecular weight of different pharmaceutical NaCMC grades,(nd)

CA Lohmann, E Sobich, ES Bochmann… - J Anal Pharm …, 2022 - researchgate.net
Sodium carboxymethylcellulose (NaCMC) is used as excipient in several marketed products
from the biopharmaceutical and food industries owing to its non-toxic biocompatible nature …