The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

The field of stereotactic neurosurgery developed more than 70 years ago to address a
therapy gap for patients with severe psychiatric disorders. In the decades since, it has …

There is now a wealth of evidence that anterior insular and anterior cingulate cortices have a
close functional relationship, such that they may be considered together as input and output …

The pursuit of happiness is a preoccupation for many people. Yet only the pursuit can be
promised, not happiness itself. Can science help? We focus on the most tractable ingredient …

Background How is happiness generated via brain function in lucky individuals who have
the good fortune to be happy? Conceptually, well-being or happiness has long been viewed …

Anhedonia is a core symptom of major depressive disorder (MDD), long thought to be
associated with reduced dopaminergic function. However, most antidepressants do not act …

To date, electroconvulsive therapy (ECT) is the most potent treatment in severe depression.
Although ECT has been successfully applied in clinical practice for over 70 years, the …

The cingulum bundle (CB) is one of the brain's major white matter pathways, linking regions
associated with executive function, decision-making, and emotion. Neuroimaging has …

Emotional information, such as reward or punishment, gains rapid and often preferential
access to neurocognitive resources. This ability to quickly evaluate and integrate emotion …

Objectives. Intensified repetitive transcranial magnetic stimulation (rTMS) applied to the left
dorsolateral prefrontal cortex (DLPFC) may result in fast clinical responses in treatment …