[HTML][HTML] Gut microbiota in health and disease

I Sekirov, SL Russell, LCM Antunes… - Physiological …, 2010 - journals.physiology.org
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the
mammalian gastrointestinal tract. The composition of this microbial community is host …

Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations

KL Becker, R Snider, ES Nylen - Critical care medicine, 2008 - journals.lww.com
Objective: The use of procalcitonin (ProCT) as a marker of several clinical conditions, in
particular, systemic inflammation, infection, and sepsis, will be clarified, and its current …

Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors

KL Becker, ES Nylen, JC White, B Muller… - The Journal of …, 2004 - academic.oup.com
Calcitonin (CT) is a hormone that received its name because of its secretion in response to
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …

Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target

KL Becker, R Snider, ES Nylen - British journal of …, 2010 - Wiley Online Library
The worldwide yearly mortality from sepsis is substantial, greater than that of cancer of the
lung and breast combined. Moreover, its incidence is increasing, and its response to therapy …

Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients

CJ Doig, LR Sutherland, J Dean Sandham… - American journal of …, 1998 - atsjournals.org
We conducted a prospective, observational cohort study designed to compare intestinal
permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a …

Macrophages and post-burn immune dysfunction

MG Schwacha - Burns, 2003 - Elsevier
The activation of a pro-inflammatory cascade after burn injury appears to be important in the
development of subsequent immune dysfunction, susceptibility to sepsis and multiple organ …

Burns, bacterial translocation, gut barrier function, and failure

LJ Magnotti, EA Deitch - The Journal of burn care & …, 2005 - academic.oup.com
The development of systemic inflammation, acute lung injury, and multiple organ failure after
a major thermal injury, as well as nonthermal forms of trauma, remain relatively common …

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

PL Sappington, R Yang, H Yang, KJ Tracey, RL Delude… - Gastroenterology, 2002 - Elsevier
Background & Aims: High mobility group (HMG) B1 is a nonhistone nuclear protein that was
recently identified as a late-acting mediator of lipopolysaccharide-induced lethality in mice …

Use of plasma procalcitonin levels as an adjunct to clinical microbiology

DN Gilbert - Journal of clinical microbiology, 2010 - Am Soc Microbiol
Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to
invasion by pathogenic bacteria, fungi, and some parasites. Current PCT assays are rapid …

The inflammatory basis of trauma/shock-associated multiple organ failure

YM Yao, H Redl, S Bahrami, G Schlag - Inflammation Research, 1998 - Springer
Multiple alterations in inflammatory and immunologic function have been demonstrated in
clinical and experimental situations after trauma and hemorrhage, in particular the activation …