The remarkable processes that characterize living organisms, such as motility, self-healing
and reproduction, are fuelled by a continuous injection of energy at the microscale. The field …

Efficient sorting of the material internalized by endocytosis is essential for key cellular
functions and represents a, if not the, major trafficking pathway in mammalian cells …

It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …

Highlights•Rab GTPases recruit distinct sets of effector proteins to membrane
microdomains.•Rab-bound effectors confer unique functionalities to membrane …

The endocytic pathway is essential for processes that define how cells interact with their
environment, including receptor signalling, cell adhesion and migration, pathogen entry …

Cells need to decode chemical or physical signals from their environment in order to make
decisions on their fate. In the case of signalling receptors, ligand binding triggers a cascade …

In addition to its long-studied presence in the cytoplasm, actin is also found in the nuclei of
eukaryotic cells. The function and form (monomer, filament, or noncanonical oligomer) of …

Epidermal growth factor (EGF) and insulin receptor tyrosine kinases (RTKs) exemplify how
receptor location is coupled to signal transduction. Extracellular binding of ligands to these …

An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-
fate decisions despite sharing the same signalling cascades. Here, we uncovered an …

The interior of a living cell is an active, fluctuating, and crowded environment, yet it maintains
a high level of coherent organization. This dichotomy is readily apparent in the intracellular …