Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

The clinical utility of doxorubicin is compromised due to dose related toxic side effects and
limited oral bioavailability with no oral formulation being marketed. Enhancement of …

Background Triple negative breast cancer (TNBC) is an immunogenically hot tumor. The
immune checkpoint blockades (ICBs) have been recently emerged as promising therapeutic …

The tumour microenvironment (TME) is a dynamic nexus where cancer cell metabolism and
the immune system intricately converge, with nucleotide metabolism (NM) playing a pivotal …

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these
treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) …

Ethnopharmacological relevance Chamaecyparis obtusa (C. obtusa, cypress species) is a
plant that grows mainly in the temperate Northern Hemisphere and has long been used as a …

This study presents a novel polyvinyl alcohol (PVA)-based nanocomposite enriched with Te
2 O 3, Cr 2 O 3, and Pr 6 O 11 oxides, aimed at enhancing optical properties and …

Different contributions of dopants based on Yttrium oxide (Y 2 O 3)/titanium (IV) oxide (TiO
2)/carbon nanotube (CNT)/have been incorporated into the polymeric matrix of Polystyrene …

Simple Summary Despite remarkable progress in immunotherapy, most advanced cancer
patients still show intrinsic or naturally acquired resistance to immune checkpoint blockade …

Energetic and nutritional requirements play a crucial role in shaping the immune cells that
infiltrate tumor and parasite infection sites. The dynamic interaction between immune cells …