Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Abstract Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous group of
disorders sharing the same clinical phenotype, characterized by distal limb muscle wasting …

In vertebrates, a family of related proteins called connexins form gap junctions (GJs), which
are intercellular channels. In the central nervous system (CNS), GJs couple …

Abstract Charcot-Marie-Tooth disease (CMT) disease encompasses a genetically
heterogeneous group of inherited neuropathies, also known as hereditary motor and …

The genetic neuropathies are a clinically and genetically heterogeneous group of diseases
of which the most common types are Charcot–Marie–Tooth disease (CMT), the hereditary …

Genetic diseases demonstrate that the normal function of CNS myelin depends on
connexin32 (Cx32) and Cx47, gap junction (GJ) proteins expressed by oligodendrocytes …

Summary Charcot‐Marie‐Tooth disease (CMT) is the most common neuromuscular
disorder. It represents a group of clinically and genetically heterogeneous inherited …

Background C harcot‐M arie‐T ooth disease (CMT) is the most common inherited disorder
of the peripheral nervous system. The frequency of different CMT genotypes has been …

Objective: To investigate possible genotype–phenotype correlations and to evaluate the
natural history of patients with Charcot–Marie–Tooth disease type 1X (CMT1X). Background …

Mice lacking the K+ channel Kir4. 1 or both connexin32 (Cx32) and Cx47 exhibit myelin-
associated vacuoles, raising the possibility that oligodendrocytes, and the connexins they …