Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

The assessment of pain is of critical importance for mechanistic studies as well as for the
validation of drug targets. This review will focus on knee joint pain associated with arthritis …

In the present study, the effect and mechanism of action of the flavonoid naringenin were
evaluated in superoxide anion donor (KO2)-induced inflammatory pain in mice. Naringenin …

Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …

Challenges have emerged following the revival of nitric oxide (NO) from 'something old', a
simple gas derived from nitrogen and oxygen with a role in the early stages of evolution, into …

Patients with tension-type headache (TTH) have an increased risk of developing arterial
hypertension (AH), while hypertensive subjects do seem to have an increased risk of TTH …

Abnormal neuronal activity in sensory ganglia contributes to chronic pain. There is evidence
that signals can spread between cells in these ganglia, which may contribute to this activity …

Non-opioid analgesics including both selective and non-selective cyclooxygenase (COX)
inhibitors and acetaminophen are the most widely used treatments for pain. Inhibition of …

Chronic pain syndromes are an important medical problem generated by various molecular,
genetic, and pathophysiologic mechanisms. Back pain, neuropathic pain, and posttraumatic …

N-arachidonoyl glycine is an endogenous arachidonoyl amide that activates the orphan G
protein-coupled receptor (GPCR) GPR18 in a pertussis toxin (PTX)-sensitive manner and …