Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation
syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening …

Interferon-γ (IFNγ) is a pleiotropic cytokine with multiple effects on the inflammatory
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …

Introduction Some COVID-19 patients have higher mortality and the responsible factors for
this unfavorable outcome is still not well understood. Objective To study the association …

Hemophagocytic lymphohistiocytosis (HLH) is a disorder that has been recognized since the
middle of the last century. In recent decades, increasing understanding of the genetic roots …

Since murine cytomegalovirus (MCMV) was first described in 1954, it has been used to
model human cytomegalovirus (HCMV) diseases. MCMV is a natural pathogen of mice that …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
condition. Primary HLH occurs early in life as a result of monogenic biallelic mutations …

Immunocompromised mouse strains expressing human transgenes are being increasingly
used in biomedical research. The genetic modifications in these mice cause various cellular …

Familial hemophagocytic lymphohistiocytosis (FHL) is a hyperinflammatory syndrome
affecting patients with genetic cytotoxicity defects. Perforin‐deficient (PKO) mice recapitulate …

Interferon-γ (IFNγ) is a pleiotropic cytokine with multiple effects on the inflammatory
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …

Hemophagocytic lymphohistiocytosis (HLH) comprises a broad spectrum of life-threatening
cytokine storm syndromes, classified into primary (genetic) or secondary (acquired) HLH …