Reconsolidation/destabilization, extinction and forgetting of fear memory as therapeutic targets for PTSD

S Kida - Psychopharmacology, 2019 - Springer
Post-traumatic stress disorder (PTSD) is a psychiatric disorder associated with memories of
traumatic experiences. Conditioned fear memory, a representative model of traumatic …

Neural computations of threat

I Levy, D Schiller - Trends in cognitive sciences, 2021 - cell.com
A host of learning, memory, and decision-making processes form the individual's response
to threat and may be disrupted in anxiety and post-trauma psychopathology. Here we review …

Understanding the dynamic and destiny of memories

L de Oliveira Alvares, FH Do-Monte - Neuroscience & Biobehavioral …, 2021 - Elsevier
Memory formation enables the retention of life experiences overtime. Based on previously
acquired information, organisms can anticipate future events and adjust their behaviors to …

3, 4-methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats

HS Hake, JKP Davis, RR Wood, MK Tanner… - Physiology & …, 2019 - Elsevier
Clinical trials have demonstrated that 3, 4-methylenedioxymethamphetamine (MDMA)
paired with psychotherapy is more effective at reducing symptoms of post-traumatic stress …

[HTML][HTML] The challenge of memory destabilisation: from prediction error to prior expectations and biomarkers

AL Milton, RK Das, E Merlo - Brain Research Bulletin, 2023 - Elsevier
The re-ignition of memory reconsolidation research sparked by Karim Nader in the early
2000s led to great excitement that 'reconsolidation-based'interventions might be developed …

Appraising reconsolidation theory and its empirical validation

N Schroyens, T Beckers, L Luyten - Psychonomic bulletin & review, 2023 - Springer
Re-exposure to elements of prior experiences can create opportunities for inducing amnesia
for those events. The dominant theoretical framework posits that such re-exposure can result …

Dopamine regulation of contextual fear and associated neural circuit function

C Stubbendorff, CW Stevenson - European Journal of …, 2021 - Wiley Online Library
Learning to associate certain contexts with threat and adapting to changing environmental
contingencies by learning that such contexts are no longer associated with threat are both …

Reminder duration determines threat memory modification in humans

J Hu, W Wang, P Homan, P Wang, X Zheng… - Scientific reports, 2018 - nature.com
Memory reminders can return a memory into an unstable state such that it will decay unless
actively restabilized into long-term memory through reconsolidation. Exposure to a memory …

Reconsolidation-based treatment for fear of public speaking: a systematic pilot study using propranolol

JWB Elsey, AI Filmer, HR Galvin, JD Kurath… - Translational …, 2020 - nature.com
Pharmacological manipulation of memory reconsolidation opens up promising new avenues
for anxiety disorder treatment. However, few studies have directly investigated …

Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities

MTJ Exton-McGuinness, AL Milton - Learning & memory, 2018 - learnmem.cshlp.org
Addiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is
thought to be driven by maladaptive learning processes which store and maintain …