The mesangial cell—the glomerular stromal cell
Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and
the glomerular response to injury. A growing body of evidence demonstrates that …
the glomerular response to injury. A growing body of evidence demonstrates that …
Development of the mammalian kidney
AP McMahon - Current topics in developmental biology, 2016 - Elsevier
The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery
Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …
disease. We report a modified human kidney organoid system that generates thousands of …
Higher-order kidney organogenesis from pluripotent stem cells
A Taguchi, R Nishinakamura - Cell stem cell, 2017 - cell.com
Organogenesis generates higher-order structures containing functional subunits, connective
components, and progenitor niches. Despite recent advances in organoid-based modeling …
components, and progenitor niches. Despite recent advances in organoid-based modeling …
Generation of kidney organoids from human pluripotent stem cells
The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …
Conserved and divergent features of mesenchymal progenitor cell types within the cortical nephrogenic niche of the human and mouse kidney
Cellular interactions among nephron, interstitial, and collecting duct progenitors drive
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells,
but its role in cell fate determination and differentiation during liver development remains …
but its role in cell fate determination and differentiation during liver development remains …
Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis
A Kobayashi, JW Mugford, AM Krautzberger, N Naiman… - Stem cell reports, 2014 - cell.com
The mammalian kidney is a complex organ consisting of multiple cell types. We previously
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …
Kidney organoids: accurate models or fortunate accidents
MH Little, AN Combes - Genes & Development, 2019 - genesdev.cshlp.org
There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …