Challenges in glioblastoma research: focus on the tumor microenvironment

A Bikfalvi, CA da Costa, T Avril, JV Barnier, L Bauchet… - Trends in cancer, 2023 - cell.com
Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

Circadian rhythms and astrocytes: the good, the bad, and the ugly

MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

The many facets of therapy resistance and tumor recurrence in glioblastoma

A Goenka, D Tiek, X Song, T Huang, B Hu, SY Cheng - Cells, 2021 - mdpi.com
Glioblastoma (GBM) is the most lethal type of primary brain cancer. Standard care using
chemo-and radio-therapy modestly increases the overall survival of patients; however …

Effect of levetiracetam use duration on overall survival of isocitrate dehydrogenase wild-type glioblastoma in adults: an observational study

J Pallud, G Huberfeld, E Dezamis, S Peeters… - Neurology, 2022 - AAN Enterprises
Background and Objectives The association between levetiracetam and survival with
isocitrate dehydrogenase (IDH) wild-type glioblastomas is controversial. We investigated …

Neural signaling in cancer

MB Keough, M Monje - Annual review of neuroscience, 2022 - annualreviews.org
Nervous system activity regulates development, homeostasis, and plasticity of the brain as
well as other organs in the body. These mechanisms are subverted in cancer to propel …

Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities

G Sprugnoli, S Rossi, A Rotenberg, A Pascual-Leone… - …, 2021 - thelancet.com
Malignant brain tumours are among the most aggressive human cancers, and despite
intensive efforts made over the last decades, patients' survival has scarcely improved …

Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives

T Hua, H Shi, M Zhu, C Chen, Y Su… - International …, 2022 - spandidos-publications.com
An increasing body of evidence has become available to reveal the synaptic and functional
integration of glioma into the brain network, facilitating tumor progression. The novel …

Animal models and human tissue compared to better understand and treat the epilepsies

G Milior, M Morin‐Brureau, J Pallud, R Miles… - …, 2023 - Wiley Online Library
Animal models of human brain disorders permit researchers to explore disease mechanisms
and to test potential therapies. However, therapeutic molecules derived from animal models …

Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy

F Giammello, C Biella, EC Priori, MADS Filippo… - Cell Communication and …, 2024 - Springer
Background Glioblastoma (GBM) stands as the most prevalent and aggressive form of adult
gliomas. Despite the implementation of intensive therapeutic approaches involving surgery …

Old stars and new players in the brain tumor microenvironment

E Parmigiani, M Scalera, E Mori, E Tantillo… - Frontiers in Cellular …, 2021 - frontiersin.org
In recent years, the direct interaction between cancer cells and tumor microenvironment
(TME) has emerged as a crucial regulator of tumor growth and a promising therapeutic …