The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a
neural circuit through which the CNS can modulate peripheral immune responses. Signals …

The vagus nerve is a mixed nerve, comprising 80% afferent fibers and 20% efferent fibers. It
allows a bidirectional communication between the central nervous system and the digestive …

Purpose Comorbidity indices are often used to measure comorbidities in register-based
research. We aimed to adapt the Charlson comorbidity index (CCI) to a Swedish setting …

Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

The vagus nerve, the great wanderer, is involved in numerous processes throughout the
body and vagus nerve stimulation (VNS) has the potential to modulate many of these …

Abstract Background and Aims Crohn's disease [CD] is a debilitating, inflammatory condition
affecting the gastrointestinal tract. There is no cure and sustained clinical and endoscopic …

The vagus nerve is a crucial component of the parasympathetic nervous system, facilitating
communication between the brain and various organs including the ears, heart, lungs …

The α7-nicotinic acetylcholine receptor (α7nAChR) is a key protein in the cholinergic anti-
inflammatory pathway (CAP) that links the nervous and immune systems. Initially, the …

The incidence of chronic inflammatory bowel diseases (IBDs), such as Crohn's disease (CD)
and ulcerative colitis (UC) have significantly increased in recent decades implicating …

The pathophysiology of inflammatory bowel diseases (IBDs) involves immunological,
genetic and environmental factors. Through its ability to sense environmental stimuli, the …