Histiocytic disorders
KL McClain, C Bigenwald, M Collin… - Nature Reviews …, 2021 - nature.com
The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …
diseases characterized by pathogenic myeloid cells that share histological features with …
Langerhans cell histiocytosis
C Rodriguez-Galindo, CE Allen - Blood, The Journal of the …, 2020 - ashpublications.org
Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors
that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ …
that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ …
Genomic profiling for clinical decision making in lymphoid neoplasms
L De Leval, AA Alizadeh, PL Bergsagel… - Blood, The Journal …, 2022 - ashpublications.org
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
Autophagy in malignant transformation and cancer progression
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …
such a homeostatic activity constitutes a robust barrier against malignant transformation …
Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages
The histiocytoses are rare disorders characterized by the accumulation of macrophage,
dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults …
dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults …
Diverse and targetable kinase alterations drive histiocytic neoplasms
EL Diamond, BH Durham, J Haroche, Z Yao, J Ma… - Cancer discovery, 2016 - AACR
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation
of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell …
of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell …
BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy
S Héritier, JF Emile, MA Barkaoui, C Thomas… - Journal of clinical …, 2016 - ascopubs.org
Purpose Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with a
broad spectrum of clinical manifestations and outcomes in children. The somatic BRAF …
broad spectrum of clinical manifestations and outcomes in children. The somatic BRAF …
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis
R Chakraborty, OA Hampton, X Shen… - Blood, The Journal …, 2014 - ashpublications.org
Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions
composed of pathological CD207+ dendritic cells with an inflammatory infiltrate …
composed of pathological CD207+ dendritic cells with an inflammatory infiltrate …
Langerhans-cell histiocytosis
Langerhans-Cell Histiocytosis A spectrum of diseases formerly known as histiocytosis X and
now called Langerhans-cell histiocytosis is characterized by ERK pathway activation …
now called Langerhans-cell histiocytosis is characterized by ERK pathway activation …
Histiocytosis
Histiocytoses constitute a heterogeneous group of rare disorders, characterised by
infiltration of almost any organ by myeloid cells with diverse macrophage or dendritic cell …
infiltration of almost any organ by myeloid cells with diverse macrophage or dendritic cell …