Covering: up to the end of 2008 This review discusses the biosynthesis of natural products
that are generated by trans-AT polyketide synthases, a family of catalytically versatile …

Appreciation that some cyclic peptide antibiotics such as gramicidin S and tyrocidine were
nonribosomally synthesized has been known for 50 years. The past two decades of …

The genome of plant-associated Bacillus amyloliquefaciens FZB42 harbors an array of giant
gene clusters involved in synthesis of lipopeptides and polyketides with antifungal …

The≈ 80-kb pksX gene cluster in Bacillus subtilis encodes an unusual hybrid polyketide/
nonribosomal peptide synthase that has been linked to the production of the …

The genome of environmental Bacillus amyloliquefaciens FZB42 harbors numerous gene
clusters involved in synthesis of antifungal and antibacterial acting secondary metabolites …

Bacillus species act as plant growth‐promoting rhizobacteria (PGPR) that can produce a
large number of bioactive metabolites. Bacillaene, a linear polyketide/nonribosomal peptide …

Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry
responsible for the formation of these compounds have revealed fascinating mechanisms …

For the characterization of protein sequences and post‐translational modifications by MS,
the 'top‐down'proteomics approach utilizes molecular and fragment ion mass data obtained …

The terminal alkyne is a functionality widely used in organic synthesis, pharmaceutical
science, material science and bioorthogonal chemistry. This functionality is also found in …

With the emergence of drug resistance and the genomic revolution, there has been a
renewed interest in the genes that are responsible for the generation of bioactive natural …