Objective: In this review, we report antimicrobial candidates containing pyrazole nucleus
integrated with various functionalities. Methods: research results by numerous scientists …

Chalcones are promising synthons and bioactive scaffolds of great medicinal interest due to
their numerous pharmacological and biological activities. They are well recognized to …

Chalcones continue to occupy a venerated status as scaffolds for the construction of a
variety of heterocyclic molecules with medicinal and industrial properties. Syntheses of …

Recently, inhibition of PIM-1 enzyme is found as an effective route in the fight against
proliferation of cancer. Herein, new cyano pyridines that target PIM-1 kinase were designed …

An efficient synthetic route to construct diverse pyrazole-based chalcones from 1-phenyl-1 H-
pyrazol-3-ols bearing a formyl or acetyl group on the C4 position of pyrazole ring, employing …

A copper-catalyzed aerobic [3+ 2] annulation reaction to access various pyrazole-bound
chalcones starting from readily available and cost-effective hydrazones and dienones is …

New pyridine‐based chalcones 4a–h and pyrazolines 5a–h (N‐acetyl), 6a–h (N‐phenyl),
and 7a–h (N‐4‐chlorophenyl) were synthesized and evaluated by the National Cancer …

Monoamine oxidase (MAO) is an enzyme involved in neurotransmitter monoamine
metabolism through an oxidative deamination reaction that produces a nerve-damaging …

Abstract The 2‐alkoxy‐3‐cyanopyridine derivatives' straightforward synthesis, ease of
structural manipulation, and variety of intriguing biological activity continue to captivate …

Abstract [eng] For the first time, new 6-(hetero) aryl-2-phenyl-5-hydroxypyrano [2, 3-c]
pyrazole-4 (2H)-ones were synthesized through four reaction stages when using readily …