The mammalian cysteine protease legumain in health and disease
R Solberg, NN Lunde, KM Forbord, M Okla… - International Journal of …, 2022 - mdpi.com
The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …
Neuromodulation for peripheral nerve regeneration: systematic review of mechanisms and in vivo highlights
While denervation can occur with aging, peripheral nerve injuries are debilitating and often
leads to a loss of function and neuropathic pain. Although injured peripheral nerves can …
leads to a loss of function and neuropathic pain. Although injured peripheral nerves can …
Phosphorylation and glycosylation of amyloid-β protein precursor: the relationship to trafficking and cleavage in Alzheimer's disease
XJ Song, HY Zhou, YY Sun… - Journal of Alzheimer's …, 2021 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder in the central nervous system,
and this disease is characterized by extracellular senile plaques and intracellular …
and this disease is characterized by extracellular senile plaques and intracellular …
Proportions of four distinct classes of sensory neurons are retained even when axon regeneration is enhanced following peripheral nerve injury
S Khan, DI Carrasco, R Isaacson… - Frontiers in …, 2023 - frontiersin.org
Introduction Recovery from peripheral nerve injuries is poor because axon regeneration is
slow and inefficient. Experimental therapies that increase signaling of neuronal brain …
slow and inefficient. Experimental therapies that increase signaling of neuronal brain …
Treatments with the specific δ‐secretase inhibitor, compound 11, promote the regeneration of motor and sensory axons after peripheral nerve injury
RH Isaacson, DI Carrasco, H Holliday… - European Journal of …, 2023 - Wiley Online Library
Limited axon regeneration following peripheral nerve injury may be related to activation of
the lysosomal protease, asparaginyl endopeptidase (AEP, δ‐secretase) and its degradation …
the lysosomal protease, asparaginyl endopeptidase (AEP, δ‐secretase) and its degradation …
Conditioning electrical stimulation fails to enhance sympathetic axon regeneration
Peripheral nerve injuries are common, and there is a critical need for the development of
novel therapeutics to complement surgical repair. Conditioning electrical stimulation (CES) …
novel therapeutics to complement surgical repair. Conditioning electrical stimulation (CES) …