Along with errors in meiosis, mitotic errors during post-zygotic cell division contribute to
pervasive aneuploidy in human embryos. Relatively little is known, however, about the …

Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

In IVF cycles, the application of aneuploidy testing at the blastocyst stage is quickly growing,
and the latest reports estimate almost half of cycles in the US undergo preimplantation …

Embryonic mosaicism, defined as the presence of karyotypically distinct cell lines within an
embryo, has been frequently reported with a high incidence in preimplantation embryos …

Modern technologies applied to the field of preimplantation genetic diagnosis for aneuploidy
screening (PGD-A) have improved the ability to identify the presence of mosaicism …

Despite next-generation sequencing, which now allows for the accurate detection of
segmental aneuploidies from in vitro fertilization embryo biopsies, the origin and …

Objective To determine whether blastocoel fluid (BF) or spent blastocyst medium (SBM) is a
suitable template for genotype and/or karyotype assessment of in vitro fertilization …

Chromosomal mosaicism is at high occurrence in early developmental-stage embryos, but
much lower in those at prenatal stage. Recent studies provided evidence on the viability of …

Defining the actual incidence and prevalence of mosaicism in human blastocysts still
remains a difficult task. The small amount of evidence generated by animal and human …

Designed to minimize chances of transferring genetically abnormal embryos,
preimplantation genetic diagnosis (PGD) involves in vitro fertilization (IVF), embryo biopsy …