Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning
efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in …

Children conceived by assisted reproductive technologies (ART) have a moderate risk for a
number of adverse events and conditions. The question whether this additional risk is …

Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency,
accompanied by dynamic changes in X chromosome activity in females. To investigate the …

In female mice, the gene dosage from X chromosomes is adjusted by a process called X
chromosome inactivation (XCI) that occurs in two steps. An imprinted form of XCI (iXCI) that …

A hallmark of chromosome organization is the partition into transcriptionally active A and
repressed B compartments, and into topologically associating domains (TADs). Both …

The mammalian germline is characterized by extensive epigenetic reprogramming during its
development into functional eggs and sperm. Specifically, the epigenome requires resetting …

Reactivation of the inactive X chromosome is a hallmark epigenetic event during
reprogramming of mouse female somatic cells to induced pluripotent stem cells (iPSCs) …

X-chromosome inactivation (XCI) is a process involved in the pathogenesis of several
diseases. In this mini review, we discuss the known mechanisms associated with XCI, when …

Humans and rodents differ in how they carry out X inactivation (XI), the mammalian method
to compensate for the different number of X chromosomes in males and females …

During gametogenesis in mammals, meiosis ensures the production of haploid gametes.
The timing and length of meiosis to produce female and male gametes differ considerably. In …