Ferroptosis as a mechanism of non-ferrous metal toxicity

M Aschner, AV Skalny, AC Martins, AI Sinitskii… - Archives of …, 2022 - Springer
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple
pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles: a possible therapeutic strategy for orthopaedic diseases: a narrative review

ZL Zeng, H Xie - Biomaterials Translational, 2022 - ncbi.nlm.nih.gov
Accumulating evidence suggests that the therapeutic role of mesenchymal stem cells
(MSCs) in bone diseases is closely related to paracrine-generated extracellular vesicles …

VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis

P Xu, B Lin, X Deng, K Huang, Y Zhang… - Free Radical Biology and …, 2022 - Elsevier
Ferroptosis plays an essential role in the pathology of osteoporosis. This study investigated
whether vitamin D receptor (VDR) activation could protect against age-related osteoporosis …

Osteoporosis in childhood cancer survivors: physiopathology, prevention, therapy and future perspectives

F Rossi, C Tortora, M Paoletta, MM Marrapodi… - Cancers, 2022 - mdpi.com
Simple Summary Anti-cancer treatments induced an increase in the childhood cancer
survival rate. However, they are responsible for several long-term side effects in childhood …

Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds

X Yu, P Liu, Z Li, Z Zhang - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes has become a global public health problem. Diabetic foot is one of the most severe
complications of diabetes, which often places a heavy economic burden on patients and …

Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling

W Li, W Li, W Zhang, H Wang, L Yu, P Yang… - Stem Cell Research & …, 2023 - Springer
Background Ferroptosis is an iron-related form of programmed cell death. Accumulating
evidence has identified the pathogenic role of ferroptosis in multiple orthopedic disorders …

[HTML][HTML] Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway

M Yang, Z Shen, X Zhang, Z Song, Y Zhang… - Free Radical Biology …, 2023 - Elsevier
Apical periodontitis (AP) is an infectious disease that causes periapical tissue inflammation
and bone destruction. Ferroptosis, a novel type of regulated cell death, is closely associated …

Maresin1 suppresses high-glucose-induced ferroptosis in osteoblasts via NRF2 activation in type 2 diabetic osteoporosis

Z Zhang, C Ji, YN Wang, S Liu, M Wang, X Xu, D Zhang - Cells, 2022 - mdpi.com
Maresin1 (MaR1) is an endogenous pro-resolving lipid mediator produced from
polyunsaturated fatty acids and is believed to have antioxidant and anti-inflammatory …

Ferroptosis: A potential target for the intervention of intervertebral disc degeneration

LP Zhou, RJ Zhang, CY Jia, L Kang… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis, an iron-dependent form of programmed cell death marked by phospholipid
peroxidation, is regulated by complex cellular metabolic pathways including lipid …

Identification of ferroptosis-associated biomarkers for the potential diagnosis and treatment of postmenopausal osteoporosis

Y Hu, J Han, S Ding, S Liu, H Wang - Frontiers in Endocrinology, 2022 - frontiersin.org
Objective Postmenopausal osteoporosis (PMOP) is one of the most commonly occurring
conditions worldwide and is characterized by estrogen deficiency as well as persistent …