N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, has revolutionized the
treatment of depression because of its potent, rapid and sustained antidepressant effects …

Ketamine has been found to have rapid and potent antidepressant activity. However, despite
the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor …

Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

The progression of glioblastomas is associated with a variety of neurological impairments,
such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of …

Background Fluoroethylnormemantine (FENM), a new Memantine (MEM) derivative,
prevented amyloid-β [25–35] peptide (Aβ25–35)-induced neurotoxicity in mice, a …

N-Methyl-D-aspartate glutamate receptors (NMDARs) are involved in multiple
physiopathological processes, including synaptic plasticity, neuronal network activities …

Understanding neurotransmitter system crosstalk in the brain is a major challenge in
neurobiology. Several intracellular and genomic cascades have been identified in this …

NMDA receptors are ligand-gated ion channels that are found throughout the brain and are
required for both brain development and many higher order functions. A variety of human …