Whitehead Institute for Biomedical Research Massachusetts Institute of Technology
Cambridge, Massachusetts 02142 pRB, the product of the retinoblastoma tumor suppressor …

The retinoblastoma susceptibility gene is a tumour suppressor and its product
retinoblastoma protein (pRb) has been known for 10 years as a repressor of progression …

HUMAN retinoblastomas can occur both as hereditary and as sporadic cases. Knudson's
proposal1 that they result from two mutational events, of which one is present in the germ …

To define a mechanism by which retinoblastoma protein (Rb) functions in cellular
differentiation, we studied primary fibroblasts from the lung buds of wild-type (RB+/+) and …

The terminal differentiation of mammalian muscle cells requires the tumor suppressor
retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes …

We have developed a universal system for temporal, spatial, and cell type–specific control of
gene expression in mice that (1) integrates the advantages of tetracycline-controlled gene …

Cells which are highly proliferative typically lack expression of differentiated, lineage-
specific characteristics. Id2, a member of the helix-loop-helix (HLH) protein family known to …

To assess the functions of the retinoblastoma protein (RB) during normal development, we
have analyzed mouse embryos that lack a functional copy of the retinoblastoma gene …

The mammalian D-type cyclins D1, D2, and D3 activate the cyclin-dependent kinases CDK4
and CDK6 in G1 and thereby promote the cell's commitment to enter S phase. To elucidate …

Homozygosity for a mutation in the Rb tumor suppressor gene causes mid‐gestation
embryonic lethality in the mouse. Using a two‐step targeting protocol, we have constructed …