Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Hematopoiesis is hierarchically orchestrated by a very small population of hematopoietic
stem cells (HSCs) that reside in the bone-marrow niche and are tightly regulated to maintain …

Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …

Hematopoietic stem cell transplantation is an effective regenerative therapy for many
malignant, inherited, or autoimmune diseases. However, our understanding of reconstituted …

Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-
associated inflammation impacts normal niches for haematopoietic progenitor cells and …

Hematopoietic stem cells (HSCs) are the ultimate source of blood and immune cells, and
transplantation reveals their unique potential to regenerate all blood lineages lifelong. HSCs …

Haematopoietic stem cells (HSCs) reside in the bone marrow and are supported by the
specialised microenvironment, a niche to maintain HSC quiescence. To deal with …

There is a hot topic in stem cell research to investigate the process of hematopoietic stem
cell (HSC) aging characterized by decreased self‐renewal ability, myeloid‐biased …

Haploidentical donor stem cell transplantation (haplo-SCT) has made great advances in
recent decades. The granulocyte colony-stimulating factor (G-CSF)-and antithymocyte …

The age of tissues and cells can be accurately estimated by DNA methylation analysis. The
multitissue DNA methylation (DNAm) age predictor combines the DNAm levels of 353 CpG …