Small open reading frames (smORFs) of 100 codons or fewer are usually—if arbitrarily—
excluded from proteome annotations. Despite this, the genomes of many metazoans …

Recombination is typically thought of as a symmetrical process resulting in large-scale
reciprocal genetic exchanges between homologous chromosomes. Recombination events …

The study of evolution at the molecular level has given the subject of evolutionary biology a
new significance. Phylogenetic'trees' of gene sequences are a powerful tool for recovering …

密码子偏性是指生物体中编码同一种氨基酸的同义密码子的非均衡使用现象,
由于这一现象与遗传信息的载体分子DNA 和生物功能分子蛋白质相关联 …

Background Correlations between genome composition (in terms of GC content) and usage
of particular codons and amino acids have been widely reported, but poorly explained. We …

The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

Analysis of genome-wide codon bias shows that only two parameters effectively differentiate
the genome-wide codon bias of 100 eubacterial and archaeal organisms. The first …

One of the most striking features of mammalian chromosomes is the variation in G+ C
content that occurs over scales of hundreds of kilobases to megabases, the so …

Unraveling the evolutionary forces responsible for variations of neutral substitution patterns
among taxa or along genomes is a major issue for detecting selection within sequences …

It is now well-established that compositional bias in DNA sequences can adversely affect
phylogenetic analysis based on those sequences. Phylogenetic analyses based on protein …