The dichotomous nature of T helper 17 cells
B Stockinger, S Omenetti - Nature Reviews Immunology, 2017 - nature.com
Abstract T helper 17 (TH17) cells have been extensively studied since their discovery 10
years ago, primarily because of their known pathogenic role in many inflammatory diseases …
years ago, primarily because of their known pathogenic role in many inflammatory diseases …
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
M DuPage, JA Bluestone - Nature Reviews Immunology, 2016 - nature.com
CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …
can also adapt their functions in response to changing circumstances. Although this …
Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T …
AG Seto, X Beatty, JM Lynch… - British journal of …, 2018 - Wiley Online Library
Summary miR‐155, a microRNA associated with poor prognosis in lymphoma and
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
Group 3 innate lymphoid cells (ILC3) are major regulators of inflammation and infection at
mucosal barriers. ILC3 development is thought to be programmed, but how ILC3 perceive …
mucosal barriers. ILC3 development is thought to be programmed, but how ILC3 perceive …
Histone modifications and their role in epigenetics of atopy and allergic diseases
B Alaskhar Alhamwe, R Khalaila, J Wolf… - Allergy, Asthma & …, 2018 - Springer
This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …
histone modifications in the development of allergic diseases, including the immune …
miR-146 and miR-155: two key modulators of immune response and tumor development
U Testa, E Pelosi, G Castelli, C Labbaye - Non-coding RNA, 2017 - mdpi.com
MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-
coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene …
coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene …
The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation
M DuPage, G Chopra, J Quiros, WL Rosenthal… - Immunity, 2015 - cell.com
Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling
is essential for establishing diverse cellular identities, but how the epigenetic program in …
is essential for establishing diverse cellular identities, but how the epigenetic program in …
MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a
changing environment by modulating the cell transcriptome. miR-155 is a multifunctional …
changing environment by modulating the cell transcriptome. miR-155 is a multifunctional …
MicroRNAs: new players in IBD
MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the …
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the …