Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

Blood contact with biomaterials triggers activation of multiple reactive mechanisms that can
impair the performance of implantable medical devices and potentially cause serious …

Our failure to produce truly non-thrombogenic materials may reflect a failure to fully
understand the mechanisms of biomaterial-associated thrombosis. The community has …

Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology
of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were …

Background: Flavonoids may be partly responsible for some health benefits, including
antiinflammatory action and a decreased tendency for the blood to clot. An acute dose of …

The oxidative status of cells is determined by the balance between pro-oxidants and
antioxidants. Pro-oxidants, referred to as reactive oxygen species (ROS), are classified into …

Sickle cell disease (SCD) is basically a red blood cell (RBC) disorder characterised by
sickling and haemolysis, but platelets and polymorphonuclear neutrophils (PMN) are also …

The plasma membrane phospholipid distribution of animal cells is markedly asymmetric.
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are concentrated in the inner …

Polyethersulfone (PES) based membranes are used for dialysis, but exposure to blood can
result in numerous interactions between the blood elements and the membrane. Adsorption …