Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Phosphate linkages govern life as we know it. Their unique properties provide the
foundation for many natural systems from cell biology and biosynthesis to the backbone of …

A growing number of organopnictogen redox catalytic methods have emerged—especially
within the past 10 years—that leverage the plentiful reversible two-electron redox chemistry …

The amidated peptides are an important class of biologically active compounds due to their
unique biological properties and wide applications as potential peptide drugs and …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

The bioconjugation of proteins—that is, the creation of a covalent link between a protein and
any other molecule—has been studied for decades, partly because of the numerous …

Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …

Through mechanistic work and rational design, we have developed the fastest
organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au (III) …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Targeted covalent inhibitors are powerful entities in drug discovery, but their application has
so far mainly been limited to addressing cysteine residues. The development of cysteine …