Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

K Nepali, S Sharma, M Sharma, PMS Bedi… - European journal of …, 2014 - Elsevier
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Coumarins: The Antimicrobial agents.

YK Al-Majedy, AAH Kadhum… - Systematic Reviews …, 2017 - search.ebscohost.com
Emergence of resistance by bacterial and fungal stains towards existing antimicrobial
agents is one of the major problem as well as motivation to synthesize a new class of …

1-Acylthiosemicarbazides, 1, 2, 4-triazole-5 (4H)-thiones, 1, 3, 4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic-anti …

U Salgın-Gökşen, N Gökhan-Kelekçi, Ö Göktaş… - Bioorganic & medicinal …, 2007 - Elsevier
Acetic acid hydrazide containing 5-methyl-2-benzoxazolinone (4) was synthesized by the
condensation of 2-(5-methyl-2-benzoxazolinone-3-yl) acetate with hydrazine hydrate …

Synthesis and antimicrobial properties of new chitosan derivatives containing guanidinium groups

A Salama, M Hasanin, P Hesemann - Carbohydrate Polymers, 2020 - Elsevier
New chitosan derivatives bearing guanidinium functions were synthesized following
different synthesis strategies. N-guanidinium chitosan acetate and N-guanidinium chitosan …

Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl− malonohydrazides and Pyridines Derivatives

MM Barqi, IM Abdellah, MR Eletmany, NM Ali… - …, 2023 - Wiley Online Library
A series of new hydrazide (3 a–j) and pyridine (11 a–j) derivatives were synthesized using a
convergent synthetic methodology by condensation of malono‐di (2‐phenylhydrazide) with …

Synthesis and pharmacological evaluation of a novel series of 5-(substituted) aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic …

S Khode, V Maddi, P Aragade, M Palkar… - European journal of …, 2009 - Elsevier
A novel series of 5-(substituted) aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines (3a–l) were
synthesized by reacting various substituted 3-aryl-1-(3-coumarinyl) propan-1-ones (2a–l) …

Synthesis of new conjugated coumarin–benzimidazole hybrids and their anticancer activity

K Paul, S Bindal, V Luxami - Bioorganic & medicinal chemistry letters, 2013 - Elsevier
A series of novel coumarin–benzimidazole hybrids, 3-(1H-benzo [d] imidazol-2-yl)-7-
(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized …

Synthesis and biological evaluation of novel tacrine derivatives and tacrine–coumarin hybrids as cholinesterase inhibitors

S Hamulakova, L Janovec, M Hrabinova… - Journal of medicinal …, 2014 - ACS Publications
A series of novel tacrine derivatives and tacrine–coumarin heterodimers were designed,
synthesized, and biologically evaluated for their potential inhibitory effect on both …

Hydrogen peroxide scavenging activity of novel coumarins synthesized using different approaches

AA Al-Amiery, YK Al-Majedy, AAH Kadhum… - PloS one, 2015 - journals.plos.org
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method
and a microwave-assisted method to compare the feasibility, reaction times, and yields of …

Coumarin triazoles as potential antimicrobial agents

SA Patil, AR Nesaragi, RR Rodríguez-Berrios… - Antibiotics, 2023 - mdpi.com
Currently, in hospitals and community health centers, microbial infections are highly
common diseases and are a leading cause of death worldwide. Antibiotics are generally …