Metallodrugs are unique: Opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review
S Thakkar, D Sharma, K Kalia, RK Tekade - Acta biomaterialia, 2020 - Elsevier
Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …
Synthesis, characterization of ruthenium (II), nickel (II), palladium (II), and platinum (II) triphenylphosphine-based complexes bearing an ONS-donor chelating agent …
SA Elsayed, HE Badr, A di Biase… - Journal of Inorganic …, 2021 - Elsevier
Four new transition metal complexes,[M (PPh 3)(L)]. CH 3 OH (M= Ni (II)(1), Pd (II)(2))[Pt
(PPh 3) 2 (HL)] Cl (3) and [Ru (CO)(PPh 3) 2 (L)](4)(H 2 L= 2, 4-dihydroxybenzaldehyde-S …
(PPh 3) 2 (HL)] Cl (3) and [Ru (CO)(PPh 3) 2 (L)](4)(H 2 L= 2, 4-dihydroxybenzaldehyde-S …
AS1411 aptamer-decorated cisplatin-loaded poly(lactic-co-glycolic acid) Nanoparticles for Targeted Therapy of miR-21-inhibited Ovarian Cancer Cells
Aim: The overexpression of miRNA-21 correlates with the cisplatin (CIS) resistance in the
ovarian cancers. Methods: AS1411 antinucleolin aptamer-decorated PEGylated poly (lactic …
ovarian cancers. Methods: AS1411 antinucleolin aptamer-decorated PEGylated poly (lactic …
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
A Solta, K Boettiger, I Kovács, C Lang… - Clinical Cancer …, 2023 - AACR
Purpose: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC),
one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have …
one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have …
[HTML][HTML] Functional gene knockout of NRF2 increases chemosensitivity of human lung cancer A549 cells in vitro and in a xenograft mouse model
Recent studies point to the evolution of drug resistance in lung cancer as being centered, at
least in part, on the upregulation of various genes involved in controlling efflux or drug …
least in part, on the upregulation of various genes involved in controlling efflux or drug …
Nickel (II) bis (isatin thiosemicarbazone) complexes induced apoptosis through mitochondrial signaling pathway and G0/G1 cell cycle arrest in IM-9 cells
C Balachandran, J Haribabu, K Jeyalakshmi… - Journal of Inorganic …, 2018 - Elsevier
Abstract Three novel complexes (1, 3 and 4) ligating N-substituted isatin thiosemicarbazone
derivatives have been synthesized and their structural and biological characteristics have …
derivatives have been synthesized and their structural and biological characteristics have …
Mixed ligand copper (II)-diimine complexes of 2-formylpyridine-N 4-phenylthiosemicarbazone: Diimine co-ligands tune the in vitro nanomolar cytotoxicity
R Kartikeyan, D Murugan, T Ajaykamal… - Dalton …, 2023 - pubs.rsc.org
Recently, mixed-ligand copper (II) complexes have received much attention in searching for
alternative metallodrugs to cisplatin. A series of mixed ligand Cu (II) complexes of the type …
alternative metallodrugs to cisplatin. A series of mixed ligand Cu (II) complexes of the type …
RNA modifications as emerging therapeutic targets
A Cayir - Wiley Interdisciplinary Reviews: RNA, 2022 - Wiley Online Library
The field of epitranscriptome, posttranscriptional modifications to RNAs, is still growing up
and has presented substantial evidences for the role of RNA modifications in diseases. In …
and has presented substantial evidences for the role of RNA modifications in diseases. In …
Enhancing the chemosensitivity of HepG2 cells towards cisplatin by organoselenium pseudopeptides
S Shaaban, SM Shabana, YS Al-Faiyz… - Bioorganic …, 2021 - Elsevier
Despite all recent advances in the treatment of hepatocellular carcinoma (HCC),
chemotherapy resistance still represents a major challenge in its successful clinical …
chemotherapy resistance still represents a major challenge in its successful clinical …