Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …

Actin filaments play multiple roles in the secretory pathway and in endosome dynamics in
mammals, including maintenance of Golgi structure, release of membrane cargo from the …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …

ER contact sites define the position of endosome bud fission during actin-dependent cargo
sorting. Disrupting endosomal actin structures prevents retrograde cargo movement; …

The plasma membrane (PM) and its associated cargo are internalized into small vesicles via
endocytosis funneling cargo into endosomes. The endosomal system must efficiently deliver …

The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …

The mechanistic target of rapamycin complex 1 (mTORC1) is part of the amino acid sensing
machinery that becomes activated on the endolysosomal surface in response to nutrient …

Actin filaments and microtubules are cytoskeletal polymers that participate in many vital cell
functions including division, morphogenesis, phagocytosis, and motility. Despite the …