Sperm and egg production requires a robust stem cell system that balances self-renewal
with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis …

The past decade of research on Drosophila stem cells and niches has provided key insights.
Fly stem cells do not occupy a special" state" based on novel" stem cell genes" but resemble …

The ability of adult stem cells to maintain their undifferentiated state depends upon
residence in their niche. While simple models of a single self-renewal signal are attractive …

Adults maintain tissue-specific stem cells through niche signals. A model for niche function is
the Drosophila melanogaster testis, where a small cluster of cells called the hub produce …

The Drosophila STAT transcription factor Stat92E regulates diverse functions, including
organ development and stem cell self-renewal. However, the Stat92E functional effectors …

The Drosophila ovariole tip produces new ovarian follicles on a 12-hour cycle by controlling
niche-based germline and follicle stem cell divisions and nurturing their developing …

Stem cells reside in specialised microenvironments, or niches, which often contain support
cells that control stem cell maintenance and proliferation. Hedgehog (Hh) proteins mediate …

Stem cell maintenance is established by neighboring niche cells that promote stem cell self-
renewal. However, it is poorly understood how stem cell activity is regulated by systemic …

Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the
Pumilio (Pum) and Nanos (Nos) translational repressors. Upon division, Dpp signaling is …

In the Drosophila ovary, germline stem cells (GSCs) physically interact with their niche
composed of terminal filament cells, cap cells, and possibly GSC‐contacting escort cells …