The application of sequencing technology is shifting from research to clinical laboratories
owing to rapid technological developments and substantially reduced costs. However …

Lower respiratory tract infections are associated with high morbidity and mortality and
significant clinical harm. Due to the limited ability of traditional pathogen detection methods …

The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well
understood, and a common cause of meningitis in this region, Mycobacterium tuberculosis …

Introduction This study aimed to evaluate the utility of metagenomic next-generation
sequencing (mNGS) for the diagnosis of Pneumocystis jirovecii pneumonia (PJP) in non …

Central nervous system (CNS) infections can be caused by various pathogens, including
bacteria, viruses, fungi, and parasites. Molecular diagnostic methods are pivotal for …

Infections lacking precise diagnosis are often caused by a rare or uncharacterized
pathogen, a combination of pathogens, or a known pathogen carrying undocumented or …

Metagenomic next-generation sequencing is a novel diagnostic test with the potential to
revolutionize the diagnosis of pediatric meningitis and encephalitis through unbiased …

The detection of a new and unexpected Japanese encephalitis virus (JEV) outbreak in
March 2022 in Australia, where JEV is not endemic, demanded the rapid development of a …

Background Identifying the causes of community-acquired pneumonia (CAP) is challenging
due to the disease's complex etiology and the limitations of traditional microbiological …

Clinical value of metagenomic next-generation sequencing (mNGS) in pneumonia
management is still controversial. A prospective study was conducted to evaluate the clinical …