Recent innovations in bacterial infection detection and treatment

C Deusenbery, Y Wang, A Shukla - ACS Infectious Diseases, 2021 - ACS Publications
Bacterial infections are a major threat to human health, exacerbated by increasing antibiotic
resistance. These infections can result in tremendous morbidity and mortality, emphasizing …

Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies

Z Si, W Zheng, D Prananty, J Li, CH Koh, ET Kang… - Chemical …, 2022 - pubs.rsc.org
The growing prevalence of antimicrobial drug resistance in pathogenic bacteria is a critical
threat to global health. Conventional antibiotics still play a crucial role in treating bacterial …

Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing

D Pranantyo, CK Yeo, Y Wu, C Fan, X Xu… - Nature …, 2024 - nature.com
Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative
stress. Current dressings that promote chronic wound healing either require additional …

Chemical basis of combination therapy to combat antibiotic resistance

Z Si, K Pethe, MB Chan-Park - JACS Au, 2023 - ACS Publications
The antimicrobial resistance crisis is a global health issue requiring discovery and
development of novel therapeutics. However, conventional screening of natural products or …

Antimicrobial peptides and macromolecules for combating microbial infections: from agents to interfaces

L Yu, K Li, J Zhang, H Jin, A Saleem… - ACS Applied Bio …, 2022 - ACS Publications
Bacterial resistance caused by the overuse of antibiotics and the shelter of biofilms has
evolved into a global health crisis, which drives researchers to continuously explore …

Nanomaterial-based strategies in antimicrobial applications: Progress and perspectives

Y Zhao, L Chen, Y Wang, X Song, K Li, X Yan, L Yu… - Nano Research, 2021 - Springer
The dramatic increase of microbial resistances against conventional available antibiotics is
a huge challenge to the effective treatment of infectious disease and thus becoming a …

A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens

M Zhou, L Liu, Z Cong, W Jiang, X Xiao, J Xie… - Nature …, 2024 - nature.com
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting
compounds, which have multiple targets on a single pathogen, offer an effective approach to …

Gradual hydrogel degradation for programable repairing full-thickness skin defect wound

C Zhou, C Sheng, J Chen, Y Liang, Q Liu, P Li… - Chemical Engineering …, 2022 - Elsevier
Full-thickness skin defect wound infection seriously threatens the life and health of patients.
Highly efficient antibacterial activity and angiogenesis after injury are critical for the wound …

Superior inhibition of virulence and biofilm formation of Pseudomonas aeruginosa PAO1 by phyto-synthesized silver nanoparticles through anti-quorum sensing …

S Kumar, BS Paliya, BN Singh - Microbial Pathogenesis, 2022 - Elsevier
Quorum sensing (QS)-regulated bacterial biofilm formation is a crucial issue in causing
resistance against existing antibiotics. There is a considerable necessity to disrupt the …

Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria

A Ottonello, JA Wyllie, O Yahiaoui… - Proceedings of the …, 2023 - National Acad Sciences
The alarming rise in superbugs that are resistant to drugs of last resort, including
vancomycin-resistant enterococci and staphylococci, has become a significant global health …