Mass spectrometry (MS)-based proteomics has become a powerful technology to quantify
the entire complement of proteins in cells or tissues. Here, we review challenges and recent …

Imaging flow cytometry combines the high-event-rate nature of flow cytometry with the
advantages of single-cell image acquisition associated with microscopy. The measurement …

Optical imaging is commonly used for both scientific and technological applications across
industry and academia. In image sensing, a measurement, such as of an object's position or …

Comprehensively charting the biologically causal circuits that govern the phenotypic space
of human cells has often been viewed as an insurmountable challenge. However, in the last …

Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …

Scalable sequence–function studies have enabled the systematic analysis and cataloging of
hundreds of thousands of coding and noncoding genetic variants in the human genome …

Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the
alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich …

Abstract The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9
nuclease system has allowed the generation of disease models and the development of …

Biological discovery has been driven by advances in throughput and resolution of analysis
technologies. They have also created an indelible bias for snapshot-based knowledge …

Assigning functions to genes and learning how to control their expression are part of the
foundation of cell biology and therapeutic development. An efficient and unbiased method to …