Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that
are released from damaged or dying cells and activate the innate immune system by …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Introduction: High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that
promotes inflammation when released extracellularly after cellular activation, stress …

Alarmins are preformed, endogenous molecules that can be promptly released to signal cell
or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 …

The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …

The nervous system and immune system have broad and overlapping distributions in the
body, and interactions of these ubiquitous systems are central to the field of …

HMGB1 is a non-histone nuclear protein that can serve as an alarmin to drive the
pathogenesis of inflammatory and autoimmune disease. Although primarily located in the …

A key question in immunology concerns how sterile injury activates innate immunity to
mediate damaging inflammation in the absence of foreign invaders. The discovery that …

During infection, vertebrates develop “sickness syndrome,” characterized by fever, anorexia,
behavioral withdrawal, acute-phase protein responses, and inflammation. These …

Abstract HMGB1 (High-Mobility Group Box-1) is a nuclear protein that acts as an
architectural chromatin-binding factor involved in the maintenance of nucleosome structure …