Physical models of collective cell motility: from cell to tissue
In this article, we review physics-based models of collective cell motility. We discuss a range
of techniques at different scales, ranging from models that represent cells as simple self …
of techniques at different scales, ranging from models that represent cells as simple self …
Collective behaviour and swarm intelligence in slime moulds
The study of collective behaviour aims to understand how individual-level behaviours can
lead to complex group-level patterns. Collective behaviour has primarily been studied in …
lead to complex group-level patterns. Collective behaviour has primarily been studied in …
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms
In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a
characteristic pattern of gene expression. Here we quantify the Shh gradient in the …
characteristic pattern of gene expression. Here we quantify the Shh gradient in the …
Cellular memory in eukaryotic chemotaxis
M Skoge, H Yue, M Erickstad, A Bae… - Proceedings of the …, 2014 - National Acad Sciences
Natural chemical gradients to which cells respond chemotactically are often dynamic, with
both spatial and temporal components. A primary example is the social amoeba …
both spatial and temporal components. A primary example is the social amoeba …
Rectified directional sensing in long-range cell migration
How spatial and temporal information are integrated to determine the direction of cell
migration remains poorly understood. Here, by precise microfluidics emulation of dynamic …
migration remains poorly understood. Here, by precise microfluidics emulation of dynamic …
The application of information theory to biochemical signaling systems
A Rhee, R Cheong, A Levchenko - Physical biology, 2012 - iopscience.iop.org
Cell signaling can be thought of fundamentally as an information transmission problem in
which chemical messengers relay information about the external environment to the …
which chemical messengers relay information about the external environment to the …
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells
Chemotaxis involves the coordinated action of separable but interrelated processes: motility,
gradient sensing, and polarization. We have hypothesized that these are mediated by …
gradient sensing, and polarization. We have hypothesized that these are mediated by …
Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
JM Yang, S Bhattacharya, H West-Foyle… - Nature …, 2018 - nature.com
The Ras-ERK signaling pathway regulates diverse cellular processes in response to
environmental stimuli and contains important therapeutic targets for cancer. Recent single …
environmental stimuli and contains important therapeutic targets for cancer. Recent single …
Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration
PR O'Neill, N Gautam - Molecular biology of the cell, 2014 - Am Soc Cell Biol
Cells sense gradients of extracellular cues and generate polarized responses such as cell
migration and neurite initiation. There is static information on the intracellular signaling …
migration and neurite initiation. There is static information on the intracellular signaling …
Adaptation in living systems
Adaptation refers to the biological phenomenon where living systems change their internal
states in response to changes in their environments in order to maintain certain key …
states in response to changes in their environments in order to maintain certain key …