A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

The prevalence of kidney diseases is emerging as a public health problem. Stem cells
(SCs), currently considered as a promising tool for therapeutic application, have aroused …

To better understand transcriptional regulation during human oogenesis and
preimplantation development, we defined stage-specific transcription, which highlighted the …

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …

The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular
memory that ensures faithful commitment to transcriptional programs during mammalian …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …

Cellular plasticity is essential for early embryonic cells. Unlike pluripotent cells, which form
embryonic tissues, totipotent cells can generate a complete organism including embryonic …

Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle
through a state characterized by decondensed chromatin and expression of transcripts …

Unlike pluripotent cells, which generate only embryonic tissues, totipotent cells can generate
a full organism, including extra-embryonic tissues. A rare population of cells resembling 2 …

Chemical reprogramming provides a powerful platform for exploring the molecular dynamics
that lead to pluripotency. Although previous studies have uncovered an intermediate …