[HTML][HTML] Nanotechnological advances for nose to brain delivery of therapeutics to improve the Parkinson therapy
Abstract Blood-Brain Barrier (BBB) acts as a highly impermeable barrier, presenting an
impediment to the crossing of most classical drugs targeted for neurodegenerative diseases …
impediment to the crossing of most classical drugs targeted for neurodegenerative diseases …
Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies
Brain, a subtle organ of multifarious nature presents plethora of physiological, metabolic and
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …
Biomaterials-enhanced intranasal delivery of drugs as a direct route for brain targeting
E Marcello, V Chiono - International Journal of Molecular Sciences, 2023 - mdpi.com
Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …
Importance of spray–wall interaction and post-deposition liquid motion in the transport and delivery of pharmaceutical nasal sprays
Nasal sprays, which produce relatively large pharmaceutical droplets and have high
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …
CFD-PK model for nasal suspension sprays: Validation with human adult in vivo data for triamcinolone acetonide
The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …
Validating CFD predictions of nasal spray deposition: Inclusion of cloud motion effects for two spray pump designs
Momentum transfer from nasal spray droplets to the surrounding gas may create droplet
cloud motion and influence nasal deposition patterns. The objective of this study was to …
cloud motion and influence nasal deposition patterns. The objective of this study was to …
Establishing quantitative relationships between changes in nasal spray in vitro metrics and drug delivery to the posterior nasal region
Nasal sprays are typically characterized using in vitro spray metrics such as spray cone
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …
Delivery of dihydroergotamine mesylate to the upper nasal space for the acute treatment of migraine: technology in action
W Cooper, S Ray, SK Aurora… - Journal of Aerosol …, 2022 - liebertpub.com
Oral tablets account for the majority of medications used to acutely treat migraine, but relief
can be limited by their rates of dissolution and absorption. The nose is an attractive …
can be limited by their rates of dissolution and absorption. The nose is an attractive …
Validation and Sensitivity analysis for a nasal spray deposition computational model
Validating numerical models against experimental models of nasal spray deposition is
challenging since many aspects must be considered. That being said, it is a critical step in …
challenging since many aspects must be considered. That being said, it is a critical step in …
INP104: a drug evaluation of a nonoral product for the acute treatment of migraine
AJ Starling, T Mallick-Searle, SB Shrewsbury… - Pain …, 2023 - Taylor & Francis
Migraine is a highly prevalent, disabling neurological disorder that is also associated with
gastrointestinal symptoms, autonomic dysfunction and allodynia. Despite the availability of …
gastrointestinal symptoms, autonomic dysfunction and allodynia. Despite the availability of …