The metabolic syndrome is an important public health concern that predisposes individuals
to the development of cardiovascular disease and/or Type 2 diabetes. The fructose-fed rat is …

Table in Reference 28). The difference between selective and mixed antagonists, however,
is not pharmacologically well defined, making antagonist studies difficult to interpret …

Endothelium-dependent vasodilation is impaired in clinical states of insulin resistance such
as obesity and type 2 diabetes. Individuals who have hyperinsulinemic insulin resistance …

Hypertensive patients have increased endothelin-1–dependent vasoconstrictor tone. This
abnormality, however, might not be uniformly present in all forms of hypertension, as …

Studies to date have provided convincing evidence that insulin has an important role in the
normal functioning of the vasculature from the perspective of the regulated delivery of …

Context: The aim of this article was to review the existing data on the interactions among
insulin, insulin resistance, and endothelin and how those contribute to the development of …

Microalbuminuria (MA), ie slightly elevated albumin excretion in the urine, is now considered
to be an atherosclerotic risk factor. MA predicts future cardiovascular disease in diabetic …

The C-reactive protein-triglyceride glucose index (CTI) is emerging as a novel indicator for
comprehensively assessing the severity of both inflammation and insulin resistance …

Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally
available and potent CXCR4 antagonists were pursued. One such proposition was …

This study was designed to examine the effects of a high-fat, high-sucrose (HFHS) diet on
vascular and metabolic actions of insulin. Male rats were randomized to receive an HFHS or …