Depression is the most frequent psychiatric comorbidity in people with epilepsy (PWE) with
lifetime prevalence rates ranging between 30 and 35%. Multifactorial variables play a …

The measurement of brain metabolites with magnetic resonance spectroscopy (MRS)
provides a unique perspective on the brain bases of neuropsychiatric disorders. As a context …

Context Major depressive disorder (MDD) is characterized by diverse metabolic and
functional abnormalities that occur in, among other regions, the pregenual anterior cingulate …

A bidirectional relation between depressive disorders and epilepsy has been suggested by
several population‐based studies and is supported by experimental studies. This article …

Single-voxel proton magnetic resonance imaging (1H-MRS) and proton MR spectroscopic
imaging (1H-MRSI) were used to compare brain metabolite levels in semi-acute mild …

Functional neuroimaging studies have converged to suggest that cortico-striatal-thalamo-
cortical (CSTC) circuit dysfunction is a core pathophysiologic feature of obsessive …

Depressive disorders are the most frequent psychiatric comorbidity in epilepsy, occurring in
one out of every three to four patients in the course of their life. Unfortunately, depressive …

Various lines of research suggest that neurotrophic processes in the hippocampus are key
mechanisms in major depressive disorder and are of relevance for response to …

Proton magnetic resonance spectroscopy (1H MRS) is a noninvasive imaging technique that
permits measurement of particular compounds or metabolites within the tissue of interest. In …

Premorbid risk for major depressive disorder (MDD) and predictors of an earlier onset and
recurrent course were examined in two studies in a large, community-based sample of …