Inherited thrombophilia and the risk of arterial ischemic stroke: a systematic review and meta‐analysis

T Chiasakul, E De Jesus, J Tong, Y Chen… - Journal of the …, 2019 - Am Heart Assoc
Background Inherited thrombophilias are well‐established predisposing factors for venous
thromboembolism, but their role in arterial thrombosis, such as arterial ischemic stroke …

WFH guidelines for the management of hemophilia

A Srivastava, E Santagostino, A Dougall… - …, 2020 - Wiley Online Library
This new edition of the World Federation of Hemophilia (WFH) guidelines for the
management of hemophilia comes at an exciting time in the evolution of the diagnosis and …

Mortality in congenital hemophilia A–a systematic literature review

CRM Hay, F Nissen, SW Pipe - Journal of Thrombosis and …, 2021 - Wiley Online Library
Against a background of a rapidly evolving treatment landscape, a contemporary, evidence‐
based consolidated understanding of mortality in people with congenital hemophilia A …

[HTML][HTML] Factor VIII: Long-established role in haemophilia A and emerging evidence beyond haemostasis

BS Bannow, M Recht, C Négrier, C Hermans… - Blood reviews, 2019 - Elsevier
Factor VIII protein (FVIII) as a coagulation replacement factor has for decades been used as
the standard of care for management of people with haemophilia A. It is effective for …

[HTML][HTML] Antithrombotic treatment in patients with hemophilia: an EHA-ISTH-EAHAD-ESO clinical practice guidance

REG Schutgens, V Jimenez-Yuste, M Escobar… - …, 2023 - journals.lww.com
Cardiovascular disease is an emerging medical issue in patients with hemophilia (PWH)
and its prevalence is increasing up to 15% in PWH in the United States. Atrial fibrillation …

[HTML][HTML] Health and treatment outcomes of patients with hemophilia in the Netherlands, 1972–2019

S Hassan, EC van Balen, C Smit… - Journal of Thrombosis …, 2021 - Elsevier
Introduction We conducted six cross‐sectional nationwide questionnaire studies among all
patients with hemophilia in the Netherlands from 1972 until 2019 to assess how health …

Emicizumab prophylaxis in haemophilia patients older than 50 years with cardiovascular risk factors: real‐world data

M Misgav, T Brutman‐Barazani, I Budnik… - …, 2021 - Wiley Online Library
Abstract Introduction Emicizumab (Hemlibra™) is approved for prophylaxis of Haemophilia
A (HA) patients with and without inhibitors. However, real‐world data on emicizumab use in …

Reduced cardiovascular morbidity in patients with hemophilia: results of a 5-year multinational prospective study

P Van Der Valk, M Makris, K Fischer, RC Tait… - Blood …, 2022 - ashpublications.org
Hemophilia is a congenital bleeding disorder caused by low levels of clotting factor VIII or IX.
The life expectancy of people with hemophilia (PWH) has increased with the availability of …

Management of comorbidities in haemophilia

CL Kempton, M Makris, PA Holme - Haemophilia, 2021 - Wiley Online Library
With the introduction of clotting factor concentrates in the early 1970s, significant
improvements in quality of life and life expectancy of persons with haemophilia (PWH) were …

Progress, and prospects in the therapeutic armamentarium of persons with congenital hemophilia. Defining the place for liver-directed gene therapy

G Di Minno, G Castaman, R De Cristofaro… - Blood Reviews, 2023 - Elsevier
In persons with congenital severe hemophilia A (HA) living in high-income countries, twice
weekly intravenous infusions of extended half-life (EHL) factor VIII (FVIII) products, or …