The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic
variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP …

Ionizing radiation is a known human carcinogen that can induce a variety of biological
effects depending on the physical nature, duration, doses and dose-rates of exposure …

BACKGROUND Multiple laboratory tests are used to diagnose and manage patients with
diabetes mellitus. The quality of the scientific evidence supporting the use of these tests …

Background: Multiple laboratory tests are used in the diagnosis and management of patients
with diabetes mellitus. The quality of the scientific evidence supporting the use of these …

Background Maturity-onset of the young (MODY) is a clinically heterogeneous form of
diabetes characterized by an autosomal-dominant mode of inheritance, an onset before the …

Individualization of therapy based on a person's specific type of diabetes is one key element
of a “precision medicine” approach to diabetes care. However, applying such an approach …

Over the last decade, we have witnessed major advances in the understanding of the
molecular basis of neonatal and infancy-onset diabetes. It is now widely accepted that …

There has been major progress in recent years uncovering the genetic causes of diabetes
presenting in the first year of life. Twenty genes have been identified to date. The most …

Single gene mutations that primarily affect pancreatic β-cell function account for
approximately 1–2% of all cases of diabetes. Overlapping clinical features with common …

Recently, a syndrome of M utant I NS-gene-induced D iabetes of Y outh (MIDY, derived from
one of 26 distinct mutations) has been identified as a cause of insulin-deficient diabetes …