Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell
disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious …

Intravascular hemolysis, or the destruction of red blood cells in the circulation, can occur in
numerous diseases, including the acquired hemolytic anemias, sickle cell disease and β …

Sickle cell disease has been described by many scholars as a chronic inflammatory disease
which is linked to many factors such as endothelial destruction, increased synthesis of …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Sickle cell disease (SCD) patients are at increased risk of red blood cell (RBC)
alloimmunization. Recipient inflammatory state at time of transfusion has been shown to …

The coronavirus disease 2019 (COVID-19) pandemic, a viral illness caused by the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), 1 has produced at the time of this …

Sickle cell disease is the most common inherited haematological disorder that leads to the
irreversible damage of multiple organs. Although sickling of red blood cells and vaso …

Inflammation, cell adhesion to vascular endothelium, and endothelial injury contribute to
sickle cell anemia (SCA) vaso-occlusion. Although alterations in inflammatory cytokines and …

BACKGROUND: Pulmonary hypertension (PHT) is common in sickle cell disease (SCD).
The purpose of this study was to determine whether markers of coagulation activation and …

Vaso-occlusive episode (VOE) is a common and critical complication of sickle cell disease
(SCD). Its pathogenesis is incompletely understood. von Willebrand factor (VWF), a …