Glia are abundant components of animal nervous systems. Recognized 170 years ago,
concerted attempts to understand these cells began only recently. From these investigations …

All epithelial components of the inner ear, including sensory hair cells and innervating
afferent neurons, arise by patterning and differentiation of epithelial progenitors residing in a …

Hox genes encode evolutionarily conserved transcription factors that specify regional
identities along the anterior-posterior (AP) axis. Although some Hox genes are known to …

Abstract Effects and mechanisms of chronic exposure to low levels of nicotine is an area
fundamentally important however less investigated. We employed the model organism …

To systematically investigate the complexity of neuron specification regulatory networks, we
performed an RNA interference (RNAi) screen against all 875 transcription factors (TFs) …

T-box genes are frequently expressed in dynamic patterns during animal development, but
the mechanisms controlling expression of these genes are not well understood. The …

T-box genes often exhibit dynamic expression patterns, and their expression levels can be
crucial for normal function. Despite the importance of these genes, there is little known about …

The nematode Caenorhabditis elegans is a simple metazoan animal that is widely used as a
model to understand the genetic control of development. The completely sequenced C …

Asymmetric divisions often produce daughter cells that differ in both fate and size. The
Caenorhabditis elegans HAM-1 protein regulates both daughter cell fate and daughter cell …

T-box transcription factors are important regulators of development in all animals, and
altered expression of T-box factors has been identified in an increasing number of diseases …