Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

The term 'genomic disorder'refers to a disease that is caused by an alteration of the genome
that results in complete loss, gain or disruption of the structural integrity of a dosage …

The history of investigations on non-B DNA conformations as related to genetic diseases
dates back to the mid-1960s. Studies with high molecular weight DNA polymers of defined …

In the yeast Saccharomyces cerevisiae, reduced levels of the replicative α DNA polymerase
result in greatly elevated frequencies of chromosome translocations and chromosome loss …

BACKGROUND Complex chromosomal rearrangements (CCRs) describe structural
rearrangements, essentially translocations, involving at least three breakpoints on two or …

Repetitive DNA motifs may fold into non‐B DNA structures, including cruciforms/hairpins,
triplexes, slipped conformations, quadruplexes, and left‐handed Z‐DNA, thereby …

Genomic rearrangements are a frequent source of instability, but the mechanisms involved
are poorly understood. A 2.5-kbp poly (purine· pyrimidine) sequence from the human PKD1 …

Understanding the developmental etiology of autistic spectrum disorders, attention
deficit/hyperactivity disorder and schizophrenia remains a major challenge for establishing …

Several recurrent, constitutional genomic disorders are present on chromosome 22q. These
include the translocations and deletions associated with DiGeorge and velocardiofacial …

Genomic disorders contribute significantly to genetic disease and, as detection methods
improve, greater numbers are being defined. Paralogous low copy repeats (LCRs) mediate …