Peptide design and self-assembly into targeted nanostructure and functional materials

NJ Sinha, MG Langenstein, DJ Pochan… - Chemical …, 2021 - ACS Publications
Peptides have been extensively utilized to construct nanomaterials that display targeted
structure through hierarchical assembly. The self-assembly of both rationally designed …

Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics

Y Ding, JP Ting, J Liu, S Al-Azzam, P Pandya, S Afshar - Amino Acids, 2020 - Springer
With the development of modern chemistry and biology, non-proteinogenic amino acids
(NPAAs) have become a powerful tool for developing peptide-based drug candidates. Drug …

Self-assembling peptide-based building blocks in medical applications

H Acar, S Srivastava, EJ Chung… - Advanced drug delivery …, 2017 - Elsevier
Peptides and peptide-conjugates, comprising natural and synthetic building blocks, are an
increasingly popular class of biomaterials. Self-assembled nanostructures based on …

Structural properties of soluble peptide amphiphile micelles

A Trent, R Marullo, B Lin, M Black, M Tirrell - Soft Matter, 2011 - pubs.rsc.org
Peptide amphiphiles (PAs) self-assemble into dynamic micellar structures that provide a
multivalent display of functional peptides and are currently being developed for use in a …

Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: Recent developments, challenges, and future perspectives

XJ Wang, J Cheng, LY Zhang, JG Zhang - Drug Delivery, 2022 - Taylor & Francis
Self-assembling peptides (SAPs) have enormous potential in medical and biological
applications, particularly noninvasive tumor therapy. SAPs self-assembly is governed by …

Harnessing the therapeutic potential of biomacromolecules through intracellular delivery of nucleic acids, peptides, and proteins

Y Tian, MV Tirrell, JL LaBelle - Advanced healthcare materials, 2022 - Wiley Online Library
Biomacromolecules have long been at the leading edge of academic and pharmaceutical
drug development and clinical translation. With the clinical advances of new therapeutics …

Active targeting of early and mid-stage atherosclerotic plaques using self-assembled peptide amphiphile micelles

LB Mlinar, EJ Chung, EA Wonder, M Tirrell - Biomaterials, 2014 - Elsevier
Inflammatory cell adhesion molecules expressed by endothelial cells on the luminal surface
of atherosclerotic plaques, such as vascular cell adhesion molecule-1 (VCAM-1), provide a …

Peptide amphiphiles as biodegradable adjuvants for efficient retroviral gene delivery

K Kaygisiz, L Rauch‐Wirth, A Iscen… - Advanced …, 2024 - Wiley Online Library
Retroviral gene delivery is the key technique for in vitro and ex vivo gene therapy. However,
inefficient virion‐cell attachment resulting in low gene transduction efficacy remains a major …

The self‐assembly of helical peptide building blocks

S Mondal, E Gazit - ChemNanoMat, 2016 - Wiley Online Library
The self‐assembly of peptide building blocks represents a central direction in
bionanotechnology. A β‐sheet secondary structure serves as the basis of numerous peptide …

Enhanced cellular entry and efficacy of tat conjugates by rational design of the auxiliary segment

P Zhang, LL Lock, AG Cheetham… - Molecular pharmaceutics, 2014 - ACS Publications
Conjugation with a cell penetrating peptide such as Tat presents an effective approach to
improve the intracellular accumulation of molecules with low membrane permeability. This …