The molecular heterogeneity of store-operated Ca2+ entry in vascular endothelial cells: the different roles of Orai1 and TRPC1/TRPC4 channels in the transition from …
F Moccia, V Brunetti, A Perna, G Guerra… - International journal of …, 2023 - mdpi.com
Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …
Activation mechanisms and structural dynamics of STIM proteins
M Sallinger, H Grabmayr, C Humer… - The Journal of …, 2024 - Wiley Online Library
The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …
[HTML][HTML] Sphingosine-1-phosphate receptor 1 activity promotes tumor growth by amplifying VEGF-VEGFR2 angiogenic signaling
The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor
vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we …
vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we …
Programming to S1PR1+ Endothelial Cells Promotes Restoration of Vascular Integrity
MZ Akhter, J Chandra Joshi… - Circulation …, 2021 - Am Heart Assoc
Rationale: Increased endothelial permeability and defective repair are the hallmarks of
several vascular diseases, including acute lung injury. However, little is known about the …
several vascular diseases, including acute lung injury. However, little is known about the …
Control of STIM and Orai function by post-translational modifications
J Johnson, R Blackman, S Gross, J Soboloff - Cell Calcium, 2022 - Elsevier
Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca 2+
sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai …
sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai …
PAR2-mediated cAMP generation suppresses TRPV4-dependent Ca2+ signaling in alveolar macrophages to resolve TLR4-induced inflammation
Alveolar macrophages (AMs), upon sensing pathogens, trigger host defense by activating
toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM …
toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM …
Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry
Exercise stimulates cellular and physiological adaptations that are associated with
widespread health benefits. To uncover conserved protein phosphorylation events …
widespread health benefits. To uncover conserved protein phosphorylation events …
L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins
MT Johnson, A Gudlur, X Zhang, P Xin… - Proceedings of the …, 2020 - National Acad Sciences
Voltage-gated L-type Ca2+ channel (Cav1. 2) blockers (LCCBs) are major drugs for treating
hypertension, the preeminent risk factor for heart failure. Vascular smooth muscle cell …
hypertension, the preeminent risk factor for heart failure. Vascular smooth muscle cell …
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway
The store-operated calcium entry (SOCE) pathway is an important route for generating
cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal …
cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal …