Olfactory dysfunction in aging and neurodegenerative diseases

X Dan, N Wechter, S Gray, JG Mohanty… - Ageing research …, 2021 - Elsevier
Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

Inhalation Aromatherapy via Brain-Targeted Nasal Delivery: Natural Volatiles or Essential Oils on Mood Disorders

J Cui, M Li, Y Wei, H Li, X He, Q Yang, Z Li… - Frontiers in …, 2022 - frontiersin.org
Mood disorders, also often referred to as affective disorders, are a group of psychiatric
illnesses that severely impact mood and its related functions. The high medical expenditures …

Spatially informed cell-type deconvolution for spatial transcriptomics

Y Ma, X Zhou - Nature biotechnology, 2022 - nature.com
Many spatially resolved transcriptomic technologies do not have single-cell resolution but
measure the average gene expression for each spot from a mixture of cells of potentially …

High-definition spatial transcriptomics for in situ tissue profiling

S Vickovic, G Eraslan, F Salmén, J Klughammer… - Nature …, 2019 - nature.com
Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …

[HTML][HTML] Molecular architecture of the mouse nervous system

A Zeisel, H Hochgerner, P Lönnerberg, A Johnsson… - Cell, 2018 - cell.com
The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …

A flexible artificial chemosensory neuronal synapse based on chemoreceptive ionogel-gated electrochemical transistor

HH Chouhdry, DH Lee, A Bag, NE Lee - Nature Communications, 2023 - nature.com
The human olfactory system comprises olfactory receptor neurons, projection neurons, and
interneurons that perform remarkably sophisticated functions, including sensing, filtration …

Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data

BF Miller, F Huang, L Atta, A Sahoo, J Fan - Nature communications, 2022 - nature.com
Recent technological advancements have enabled spatially resolved transcriptomic profiling
but at multi-cellular pixel resolution, thereby hindering the identification of cell-type-specific …

Nanomaterials for flexible neuromorphics

G Ding, H Li, JY Zhao, K Zhou, Y Zhai, Z Lv… - Chemical …, 2024 - ACS Publications
The quest to imbue machines with intelligence akin to that of humans, through the
development of adaptable neuromorphic devices and the creation of artificial neural …

SM-Omics is an automated platform for high-throughput spatial multi-omics

S Vickovic, B Lötstedt, J Klughammer, S Mages… - Nature …, 2022 - nature.com
The spatial organization of cells and molecules plays a key role in tissue function in
homeostasis and disease. Spatial transcriptomics has recently emerged as a key technique …

Principles of odor coding in vertebrates and artificial chemosensory systems

I Manzini, D Schild, C Di Natale - Physiological reviews, 2022 - journals.physiology.org
The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …