In industrialized countries, cancer is the second leading cause of death after cardiovascular
disease. Most cancer patients die because of metastases, which consist of the self …

The skin is the body's largest organ. It serves as a barrier to pathogen entry and the first site
of immune defense. In the event of a skin injury, a cascade of events including inflammation …

The natural history of heart failure (HF) is not linear, because changes in the heart structure
and function start long before the disease becomes clinically evident. Many different …

Objectives Locoregional and lymphovascular involvement of invasive head and neck
squamous cell carcinoma (HNSCC) complicates curative treatment. Matrix …

Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in
tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer …

During the progression of epithelial cancer, the cells may lose epithelial markers and gain
mesenchymal phenotype via Epithelial-Mesenchymal Transition (EMT). Such transformation …

Melatonin, the primary hormone produced by the pineal gland, is intensely assessed for its
anticancer properties. This study aimed to reveal the clinical significance of serum melatonin …

Metastasis is the cause for 90% of cancer-related mortalities. Identification of genetic drivers
promoting dissemination of tumor cells may provide opportunities for novel therapeutic …

Purpose Heart failure (HF) is considered to be a complex syndrome associated with
neurohormonal and cytokine activation, that contribute to its progression. There are …

Matrix-metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) expression levels have
been demonstrated to have prognostic value in oral squamous cell carcinoma (OSCC). The …