Targeting ferroptosis: paving new roads for drug design and discovery

Y Gu, Y Li, J Wang, L Zhang, J Zhang… - European Journal of …, 2023 - Elsevier
Ferroptosis, first proposed in 2012, is an iron-dependent form of regulated cell death
characterized by excessive polyunsaturated fatty acid oxidation. In the past decade …

Ferroptosis and its role in chronic diseases

W Hu, K Liang, H Zhu, C Zhao, H Hu, S Yin - Cells, 2022 - mdpi.com
Ferroptosis, which has been widely associated with many diseases, is an iron-dependent
regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits …

Ferroptosis: From regulation of lipid peroxidation to the treatment of diseases

Y Lv, M Wu, Z Wang, J Wang - Cell Biology and Toxicology, 2023 - Springer
Ferroptosis is a regulated cell death mainly manifested by iron-dependent lipid peroxide
accumulation. The leading cause of ferroptosis is the imbalance of intracellular oxidative …

Context-dependent regulation of ferroptosis sensitivity

L Magtanong, GD Mueller, KJ Williams, M Billmann… - Cell chemical …, 2022 - cell.com
Ferroptosis is an important mediator of pathophysiological cell death and an emerging target
for cancer therapy. Whether ferroptosis sensitivity is governed by a single regulatory …

[HTML][HTML] Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application

N Liu, M Chen - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ferroptosis and cuproptosis, regulated forms of cell death resulting from metal ion
accumulation, are closely related in terms of occurrence, cell metabolism, signaling …

Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke

J Tao, J Li, X Fan, C Jiang, Y Wang, M Qin… - Ageing Research …, 2024 - Elsevier
The impact of stroke on global health is profound, with both high mortality and morbidity
rates. This condition can result from cerebral ischemia, intracerebral hemorrhage (ICH), and …

[HTML][HTML] IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke

W Wu, Z Luo, D Shen, T Lan, Z Xiao, M Liu, L Hu, T Sun… - Redox Biology, 2024 - Elsevier
Accumulation of reactive oxygen species (ROS), especially on lipids, induces massive cell
death in neurons and oligodendrocyte progenitor cells (OPCs) and causes severe …

SATB1/SLC7A11/HO-1 Axis ameliorates ferroptosis in neuron cells after ischemic stroke by Danhong injection

S Zhan, J Liang, H Lin, J Cai, X Yang, H Wu, J Wei… - Molecular …, 2023 - Springer
Neuronal damage after ischemic stroke (IS) is frequently due to ferroptosis, contributing
significantly to ischemic injury. However, the mechanism against ferroptosis in IS remained …

The crosstalk between oncogenic signaling and ferroptosis in cancer

Q Pang, Z Tang, L Luo - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
Ferroptosis, a novel form of cell death regulation, was identified in 2012. It is characterized
by unique features that differentiate it from other types of cell death, including necrosis …

Ferroptosis: A potential therapeutic target for Alzheimer's disease

L Yang, J Nao - Reviews in the Neurosciences, 2023 - degruyter.com
The most prevalent dementia-causing neurodegenerative condition is Alzheimer's disease
(AD). The aberrant buildup of amyloid β and tau hyperphosphorylation are the two most well …