Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Covering: 2002 to September 2009 In recent years, a number of gene clusters involved in
the biosynthesis of polyketide compounds have been characterized and the genes have …

Glycosylated natural products have served as reliable platforms for the development of
many existing front-line drugs. In an effort to explore the contribution of the sugar …

Bioactive natural products are frequently glycosylated with saccharide chains of different
length, in which the sugars contribute to specific interactions with the biological target …

In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant
glycosylated natural products, chemists have developed glycosylation methods that are …

In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant
glycosylated natural products, chemists have developed glycosylation methods for the …